SMO

[Cell Death & Disease] Colorectal cancer cells hijacked prostaglandin E2 (PGE2) to non-canonically promote Hedgehog transcriptional factor Gli activity and Gli-dependent proliferation of colorectal cancer cells in a Smo-independent manner.

[Cell Death Discovery] Scientists revealed that the smoothened cascade was upregulated in benign prostatic hyperplasia tissues and was localized in both the stromal and the epithelium compartments of human prostate tissues.

[Oncogene] Researchers identified a novel SOX2-BRD4 transcriptional complex driving the expression of GLI1, the final effector of the Hedgehog/GLI (HH/GLI) pathway, providing a novel mechanism of non-canonical Smoothened-independent activation of HH/GLI signaling in melanoma.

[Prostate] Scientists assessed the expression of key genes involved in hedgehog signaling in prostate cancer and investigated the potential role of smoothened in the pathogenesis of neuroendocrine prostate cancer.

[Hepatology] Investigators found that mesenchymal stem cell CD47 and macrophage signal regulatory protein alpha expression were increased after LPS stimulation.

[Cancers] Researchers demonstrated that malignant melanoma cell motility was impaired by targeting carbonic anhydrase IX via either carbonic anhydrase inhibitors or through the inhibition of the Hedgehog pathway.