Home Newsletters Intestinal Cell News PGE2-JNK Signaling Axis Non-Canonically Promotes Gli Activation by Protecting Gli2 from Ubiquitin-Proteasomal...

PGE2-JNK Signaling Axis Non-Canonically Promotes Gli Activation by Protecting Gli2 from Ubiquitin-Proteasomal Degradation

Justin.choi

July 15, 2021

Colorectal cancer cells hijacked prostaglandin E2 (PGE2) to non-canonically promote Hedgehog transcriptional factor Gli activity and Gli-dependent proliferation of colorectal cancer cells in a Smo-independent manner.

[Cell Death & Disease]

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