STAT3

[Bioengineered] Researchers verified that treatment with the STAT3 activator had significant reversal effects on the malignant behaviors of cervical cancer (CC) cells and CC stemness.

[Theranostics] In vivo subcutaneous tumor xenograft model, azoxymethane/dextran sodium sulfate -induced tumor mouse model and in vitro co-culture assays were used to investigate the Hmga2 role in tumor-associated macrophages recruitment and polarization.

[Nature Metabolism] Researchers identified the myokine/cytokine Meteorin-like (Metrnl) as a critical regulator of muscle regeneration.

[Science Signaling] Scientists studied the role of YAP/TAZ signaling in endothelial cells (ECs) in tumor angiogenesis and found that the expression of YAP/TAZ and downstream target genes in ECs correlated with tumor vascularization in human colorectal carcinomas and skin melanoma.

[Immunity] Inhibition of IL-10R signaling altered chromatin accessibility and disrupted cooperativity between the transcription factors NFAT and AP-1, promoting a distinct NFAT-associated program.

[Proceedings of the National Academy of Sciences of the United States of America] Exposure of mouse CD4+ T cells to TNF and TGF-β generated Th17 cells that expressed low levels of IL-17 and high levels of inflammatory markers independently of IL-6 and STAT3.