STAT3

[Journal of Bone and Mineral Research] In estrogen receptor positive (ER+) cells, oncostatin M (OSM) robustly stimulated phosphorylation of known gp130 signaling targets STAT3, ERK and AKT, while CNTF activated STAT3 signaling. In ER- breast cancer cells, OSM alone stimulated AKT and ERK signaling.

[Cell Death & Disease] Scientists demonstrated that radiation exposure in mice promoted the expansion of splenic and intestinal myeloid-derived suppressor cells and caused intestinal inflammation due to the increased secretion of cytokines.

[Journal of Experimental & Clinical Cancer Research] TCGA analysis was performed to identify the clinical relevance of short stature homeobox 2 (SHOX2) in breast cancer. Molecular regulations and alterations were assessed by Western blotting, immunoprecipitation, immunohistochemistry, qRT-PCR, chromatin immunoprecipitation coupled with qPCR, and ChIP/re-ChIP.

[Cell Reports] The authors reported that the LGALS1 gene, encoding the carbohydrate binding protein, galectin1, is a key regulator of brain tumor stem cells and glioblastoma resistance to therapy.

[Cancer Gene Therapy] Cell counting kit-8 assay and colony formation assay were used to measure the proliferation of pancreatic cancer cells. RNA immunoprecipitation and Western blot were employed for investigation the binding between circPTPN22 and STAT3.

[Cell Reports] Scientists showed that intestine-draining mesenteric lymph nodes, not intestine proper, were the dominant site of segmented filamentous bacteria-induced intestinal Th17 cell differentiation.