STAT3

[Translational Oncology] Scientists identified a novel mechanism of biphasic activation of STAT3 in response to gp130-linked cytokines, including interleukin-6 (IL6), in which activation of STAT3 is prolonged by circumventing the negative regulatory mechanisms induced by its initial activation

[Nature Communications] Scientists developed and utilized a capture-based sequencing panel, which covered host hotspot genes and the full-length genome of human T-cell leukemia virus type-1, to investigate the clonal architecture of adult T-cell leukemia-lymphoma.

[Scientific Reports] Scientists showed that interaction with tumor microenvironment elements, mainly activated monocytes through IL-6 secretion, and the extracellular matrix protein fibronectin, induced the Stat3 transcriptional pathway and upregulated ODZ1 which resulted in glioblastoma cell migration.

[Cell Biology International] Scientists treated human colon cancer oxaliplatin-resistant cells with oxaliplatin combined with natural product erianin, evaluated the impact of erianin on drug resistance, and explored the relationship between erianin- related oxaliplatin resistance and JAK2/STAT3 signaling pathway in vitro.

[Acta Pharmacologica Sinica] Scientists investigated the effect and underlying mechanism of (R)-4,6-dimethoxy-3-(4-methoxy phenyl)-2,3-dihydro-1H-indanone on acute pancreatitis.

[Phytotherapy Research] Researchers reported a compound, trilobolide-6-O-isobutyrate, isolated from the flowers of Wedelia trilobata with a markedly cytotoxic effect on hepatocellular carcinoma cells.