STAT3

[Frontiers in Molecular Biosciences] In vitro genetic ablation of golgi phosphoprotein 3 (GOLPH3) was performed using small interfering RNA transfection, and a stably overexpressed GOLPH3 colon cancer cell line was constructed using the lentivirus system.

[Scientific Reports] Investigators found that the zinc complex of 3,5-di-tert-butyl salicylate compound inhibited viability, invasion, and migration and induced apoptosis in triple-negative breast cancer 4T1 cells.

[Frontiers in Oncology] The authors cover the current biological understanding of the interleukin-6 (IL-6) signaling pathway and its impact on breast cancer metastasis, as well as, therapeutic interventions that target components of the IL-6 pathway.

[Cell Reports] Signal transduction and activator of transcription 3 (STAT3) activation increased migration and profibrotic signaling in genome-edited, pericyte-like cells. Conversely, blocking Stat3 inhibited detachment, migration, and profibrotic signaling.

[Cell Death & Disease] Scientists reported the role of Lon in the response to cisplatin-induced mtDNA damage and oxidative stress, which conferred cancer cells on cisplatin resistance via modulating calcium levels in mitochondria and cytosol.

[Experimental & Molecular Medicine] Scientists showed that bone marrow-derived MSCs contributed to fibrosis in myeloproliferative neoplasms by differentiating into αSMA-positive myofibroblasts.