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STAT3

Hepcidin in Hepatocellular Carcinoma

[British Journal of Cancer] The authors explore hepcidin in HCC, presenting the levels of tissue and serum hepcidin and explaining the mechanisms that contribute to hepcidin reduction in HCC.

STAT3 Inhibition Suppresses Adaptive Survival of ALK-Rearranged Lung Cancer Cells through Transcriptional Modulation of Apoptosis

[npj Precision Oncology] STAT3 inhibition effectively suppressed the adaptive survival of anaplastic lymphoma kinase (ALK)-rearranged lung cancer cells by enhancing ALK inhibition-induced apoptosis.

Novel Treatment Strategy for NRAS-Mutated Melanoma through a Selective Inhibitor of CD147/VEGFR-2 Interaction

[Oncogene] Researchers showed that CD147i, a specific inhibitor of CD147/VEGFR-2 interaction represented a potential therapeutic strategy for NRASmut melanoma cells.

Extracellular ATP Promotes Breast Cancer Chemoresistance via HIF-1α Signaling

[Cell Death & Disease] The authors reported that hypoxia-inducible factor 1α (HIF-1α) was upregulated after ATP treatment and mediated the ATP-driven chemoresistance process.

Qi Ling Decreases Paclitaxel Resistance in the Human Prostate Cancer by Reversing Tumor-Associated Macrophages Function

[Aging] Investigators administrated Qi Ling (QL) to rats and collected the serum from QL-treated rats and established the co-culture system of tumor-associated macrophages/paclitaxel resistant prostate cancer cells.

Targeting Polarized Phenotype of Microglia via IL6/JAK2/STAT3 Signaling to Reduce NSCLC Brain Metastasis

[Signal Transduction and Targeted Therapy] Scientists indicated that targeting IL6/JAK2/STAT3 signaling in activated microglia might be a promising new approach for inhibiting brain metastasis in NSCLC patients.

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