STAT3

[Nature Communications] Scientists showed that IL-18 was a bona fide IL-22-regulated gate keeper for intestinal epithelial barrier.

[Endocrine Journal] Researchers investigated the therapeutic effect of human umbilical cord MSCs on experimental autoimmune thyroiditis (EAT) and the underlying mechanisms by utilizing a porcine thyroglobulin-induced EAT rat model.

[Biophysical Journal] The authors demonstrated that T cells exposed to high-e dose-dependently accumulated [K+]e intracellularly.

[Oncogene] Scientists created type I interferon (IFN)α-overexpressing MSCs. Upon direct injection into tumors, they found that these cells were powerful in eliminating several types of tumors.

[Nature Aging] Pharmacological inhibition of Stat3 activation or genetic ablation of Stat3 in chondrocytes reversed aberrant accumulation of Runx2 and ECM-degrading enzymes and limited osteoarthritis deteriorations caused by kindlin-2 deficiency.

[Nature Communications] Integrated copy number and transcriptome analysis of 302 TNBC patients revealed that gene alpha-endosulfine (ENSA) exhibited recurrent amplification at the 1q21.3 region and was highly expressed in TNBC.