Sox2

[eLife] Using a newly derived carcinogen transformed human cell model, researchers demonstrated that fine-tuned Drp1 repression primed a slow cycling 'stem/progenitor-like state', which was characterized by small networks of fused mitochondria and a gene-expression profile with elevated functional stem/progenitor markers and their regulators.

[Molecular Therapy] The function of the only gene overexpressed in both chemoresistant tumors and tumor tissue relative to normal gastric epithelia, FOXC1, was examined in gastric adenocarcinoma cells, mouse xenograft models, and patient-derived organoid systems, focusing on cancer stem-like cell phenotypes, metastasis, and chemoresistance

[npj Breast Cancer] To find metastatic recurrence biomarkers of TNBC treated by neoadjuvant chemotherapy and anti-EGFR antibodies, investigators evaluated tumor genomic, transcriptomic, and immune features, using MSK-IMPACT assay, gene arrays, Nanostring technology, and TIL assessment on H&E.

[Cell Biology International] CD133+ cells were sorted from prostate cancer cells using magnetic fluorescence cell sorting technology and were considered as cancer stem cells.

[Development] Researchers reported that the conjunct activity of two orphan nuclear receptors, Esrrb and Nr5a2, paralleled the importance of that of Oct4 and Sox2 in naïve mouse ESCs. By occupying a large common set of regulatory elements, these two factors controlled the binding of Oct4, Sox2 and Nanog to DNA.

[Anti-Cancer Drugs] Colon cancer stem cells were selected and high/low expression of miR-148a/152 plasmids were synthesized to intervene CD44+/CD133+ colon cancer stem cells to investigate the function of miR-148a/152 in invasion, migration, proliferation, colony formation and apoptosis of cells.