FOXC1 Modulates Stem-Like Cell Properties and Chemoresistance through Hedgehog and EMT Signaling in Gastric Adenocarcinoma

The function of the only gene overexpressed in both chemoresistant tumors and tumor tissue relative to normal gastric epithelia, FOXC1, was examined in gastric adenocarcinoma cells, mouse xenograft models, and patient-derived organoid systems, focusing on cancer stem-like cell phenotypes, metastasis, and chemoresistance