Nectin-4 and p95-ErbB2 Cooperatively Regulate Hippo Signaling-Dependent SOX2 Gene Expression, Enhancing Anchorage-Independent T47D Cell Proliferation

The authors found that nectin-4 and p95-ErbB2, but not nectin-4 and either ErbB2 or ErbB2∆Ex16, cooperatively enhanced SOX2 gene expression and cell proliferation in a suspension culture.
[Scientific Reports]
Kedashiro, S., Kameyama, T., Mizutani, K., & Takai, Y. (2021). Nectin-4 and p95-ErbB2 cooperatively regulate Hippo signaling-dependent SOX2 gene expression, enhancing anchorage-independent T47D cell proliferation. Scientific Reports, 11(1), 7344. https://doi.org/10.1038/s41598-021-86437-2 Cite
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TFEB Regulates Pluripotency Transcriptional Network in Mouse Embryonic Stem Cells Independent of Autophagy–Lysosomal Biogenesis

Scientists proposed a novel mechanism for transcription factor EB (TFEB) governing pluripotency of mESCs by regulating the pluripotency transcriptional network.
[Cell Death & Disease]
Tan, A., Prasad, R., & Jho, E. (2021). TFEB regulates pluripotency transcriptional network in mouse embryonic stem cells independent of autophagy–lysosomal biogenesis. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03632-9 Cite
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Induced Pluripotent Stem Cell Technology: Trends in Molecular Biology, from Genetics to Epigenetics

The authors reviewed the molecular basis of reprogramming, including the reprogramming factors, applied vectors and epigenetic modifications to provide a comprehensive guide for reprogramming studies.
[Epigenomics]
Maali, A., Maroufi, F., Sadeghi, F., Atashi, A., Kouchaki, R., Moghadami, M., & Azad, M. (2021). Induced pluripotent stem cell technology: trends in molecular biology, from genetics to epigenetics. Epigenomics. https://doi.org/10.2217/epi-2020-0409 Cite
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MiR-142-3p Targets HMGA2 and Suppresses Breast Cancer Malignanc

The authors demonstrated that the miRNA miR-142-3p directly targeted the 3′ untranslated region of HMGA2, which encoded an onco-embryonic protein that was overexpressed in most cancers, including breast cancer.
[Life Sciences]
Mansoori, B., Duijf, P. H. G., Mohammadi, A., Safarzadeh, E., Ditzel, H. J., Gjerstorff, M. F., Cho, W. C.-S., & Baradaran, B. (2021). MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy. Life Sciences, 119431. https://doi.org/10.1016/j.lfs.2021.119431 Cite
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Rapid Reprogramming of Tumor Cells into Cancer Stem Cells on Double-Network Hydrogels

Researchers showed that a double-network hydrogel could rapidly reprogram differentiated cancer cells into cancer stem cells.
[Nature Biomedical Engineering]
Suzuka, J., Tsuda, M., Wang, L., Kohsaka, S., Kishida, K., Semba, S., Sugino, H., Aburatani, S., Frauenlob, M., Kurokawa, T., Kojima, S., Ueno, T., Ohmiya, Y., Mano, H., Yasuda, K., Gong, J. P., & Tanaka, S. (2021). Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels. Nature Biomedical Engineering, 1–12. https://doi.org/10.1038/s41551-021-00692-2 Cite
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HIF1α/HIF2α–Sox2/Klf4 Promotes the Malignant Progression of Glioblastoma via the EGFR–PI3K/AKT Signaling Pathway with Positive Feedback under Hypoxia

Scientists discovered that glioblastoma cells exhibited features indicative of malignant progression and were present in a hypoxic environment.
[Cell Death & Disease]
HIF1α/HIF2α–Sox2/Klf4 promotes the malignant progression of glioblastoma via the EGFR–PI3K/AKT signalling pathway with positive feedback under hypoxia | Cell Death & Disease. (n.d.). Retrieved March 24, 2021, from https://www.nature.com/articles/s41419-021-03598-8 Cite
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p97/VCP Is Highly Expressed in the Stem-Like Cells of Breast Cancer and Controls Cancer Stemness Partly through the Unfolded Protein Response

Researchers examined p97 expression in the stem-like cancer cells or cancer stem cells (CSCs), a cell population that purportedly underscores cancer initiation, therapeutic resistance, and recurrence.
[Cell Death & Disease]
Li, C., Huang, Y., Fan, Q., Quan, H., Dong, Y., Nie, M., Wang, J., Xie, F., Ji, J., Zhou, L., Zheng, Z., & Wang, L. (2021). p97/VCP is highly expressed in the stem-like cells of breast cancer and controls cancer stemness partly through the unfolded protein response. Cell Death & Disease, 12(4), 1–16. https://doi.org/10.1038/s41419-021-03555-5 Cite
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The Effect of hsa-miR-451b Knockdown on Biological Functions of Gastric Cancer Stem-Like Cells

Gastric cancer stem-like cells were transfected by hsa-miR-451b inhibitor then researchers used real-time RT-PCR to evaluate its effect on the expression of hsa-miR-451b and two of its direct target genes, stemness markers such as KLF4, SOX2, CD44, OCT3/4 and NANOG genes.
[Biochemical Genetics]
Farahani, D. B., Akrami, H., Moradi, B., Mehdizadeh, K., & Fattahi, M. R. (2021). The Effect of hsa-miR-451b Knockdown on Biological Functions of Gastric Cancer Stem-Like Cells. Biochemical Genetics. https://doi.org/10.1007/s10528-021-10057-8 Cite
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CDK8 Maintains Stemness and Tumorigenicity of Glioma Stem Cells by Regulating the C-MYC Pathway

Investigators demonstrated how cyclin-dependent kinase 8 (CDK8) played an essential role in maintaining stemness and tumorigenicity in glioma stem cells.
[Oncogene]
Fukasawa, K., Kadota, T., Horie, T., Tokumura, K., Terada, R., Kitaguchi, Y., Park, G., Ochiai, S., Iwahashi, S., Okayama, Y., Hiraiwa, M., Yamada, T., Iezaki, T., Kaneda, K., Yamamoto, M., Kitao, T., Shirahase, H., Hazawa, M., Wong, R. W., … Hinoi, E. (2021). CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway. Oncogene, 1–13. https://doi.org/10.1038/s41388-021-01745-1 Cite
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The Multi-Target Small-Molecule Inhibitor SB747651A Shows In Vitro and In Vivo Anticancer Efficacy in Glioblastomas

The authors investigated the anticancer effects of SB747651A, a multi-target small-molecule inhibitor, in three well characterized patient-derived glioblastoma spheroid cultures and a murine orthotopic xenograft model.
[Scientific Reports]
Knudsen, A. M., Boldt, H. B., Jakobsen, E. V., & Kristensen, B. W. (2021). The multi-target small-molecule inhibitor SB747651A shows in vitro and in vivo anticancer efficacy in glioblastomas. Scientific Reports, 11(1), 6066. https://doi.org/10.1038/s41598-021-85536-4 Cite
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MiR-301 Regulates the SIRT1/SOX2 Pathway via CPEB1 in the Breast Cancer Progression

Scientists found specific miRs involved in the progression of breast cancer, and explored the underlying molecular mechanism.
[Molecular Therapy-Oncolytics]
Jia, Y., Zhao, J., Yang, J., Shao, J., & Cai, Z. (2021). MiR-301 regulates the SIRT1/SOX2 pathway via CPEB1 in the breast cancer progression. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2021.03.007 Cite
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