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Dinaciclib Inhibits the Stemness of Two Subtypes of Human Breast Cancer Cells by Targeting the FoxM1 and Hedgehog Signaling Pathway

[Oncology Reports] Investigators aimed to examine the stemness‑inhibitory effects of dinaciclib in MCF‑7 and HCC‑1806 breast cancer cells.

LncRNA PCAT1 Activates SOX2 and Suppresses Radioimmune Responses via Regulating cGAS/STING Signaling in Non-Small Cell Lung Cancer

[Clinical and Translational Medicine] Investigators explored the impacts of prostate cancer-associated ncRNA transcripts 1 (PCAT1) on tumorigenesis and radioimmune responses and the underlying molecular mechanisms in NSCLC.

Ubiquitin-Specific Protease 1 Inhibition Sensitizes Hepatocellular Carcinoma Cells to Doxorubicin by Ubiquitinated Proliferating Cell Nuclear Antigen–Mediated Attenuation of Stemness

[Anti-Cancer Drugs] Scientists investigate the effect of Ubiquitin-specific protease 1 (USP1) depletion with chemotherapeutant doxorubicin on the hepatocellular carcinoma cells.

Matrix Stiffness-Induced Upregulation of Histone Acetyltransferase KAT6A Promotes Hepatocellular Carcinoma Progression through Regulating SOX2 Expression

[British Journal of Cancer] Scientists demonstrated that lysine acetyltransferase 6 A (KAT6A) expression was upregulated in HCC tissues and cell lines. Clinical analysis showed that increased KAT6A was significantly associated with malignant prognostic features and shorter survival.

UPF1 Contributes to the Maintenance of Endometrial Cancer Stem Cell Phenotype by Stabilizing LINC00963

[Cell Death & Disease] Scientists showed that the expression of UPF1 was upregulated in endometrial cancer tissues and endometrial cancer stem cells and correlated with poor clinicopathological characteristics.

Claudin1 Decrease Induced by 1,25-Dihydroxy-Vitamin D3 Potentiates Gefitinib Resistance Therapy through Inhibiting AKT Activation-Mediated Cancer Stem-Like Properties in NSCLC Cells

[Cell Death Discovery] Researchers performed GEO dataset analysis and identified that claudin1 was a critical regulator of epidermal growth factor receptor tyrosine kinase inhibitors resistance in NSCLC cells.