Tag Archives: Sox2

Parallel Functional Assessment of m6A Sites in Human Endodermal Differentiation with Base Editor Screens

The authors developed an adenine base editor-based strategy to systematically identify functional m6A sites that controlled lineage decisions of human #ESCs.
[Nature Communications]
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Deregulation of the CD44-NANOG-MDR1 Associated Chemoresistance Pathways of Breast Cancer Stem Cells Potentiates the Anti-cancer Effect of Kaempferol in Synergism with Verapamil

Researchers used Kaempferol in combination with Verapamil, in multiple assays to determine if there was an inhibitory effect on breast cancer stem cells.
[Toxicology and Applied Pharmacology]
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FOXM1 Mediates GDF-15 Dependent Stemness and Intrinsic Drug Resistance in Breast Cancer

The expressions and interactions of GDF-15, FOXM1, and stemness (OCT4 and SOX2), and drug resistance (ABCC5) markers were evaluated in breast cancer.
[Molecular Biology Reports]
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ZFP207 Sustains Pluripotency by Coordinating OCT4 Stability, Alternative Splicing and RNA Export

The authors employed multiple functional analyses to characterize the role of Zinc Finger Protein 207 (ZFP207) in mouse ESCs.
[EMBO Reports]
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p57 Suppresses the Pluripotency and Proliferation of Mouse Embryonic Stem Cells by Positively Regulating p53 Activation

Scientists discovered that p57Kip2 (p57), a cyclin-dependent kinase inhibitor canonically inhibiting cell proliferation, played a role in suppressing the pluripotency state of mouse ESCs.
[Stem Cells International]
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HIF1α/HIF2α Induces Glioma Cell Dedifferentiation into Cancer Stem Cells through Sox2 under Hypoxic Conditions

Scientists performed a series of experiments to verify whether HIF1α, HIF2α and Sox2 regulated glioma cell dedifferentiation under hypoxic conditions. Sphere formation by single glioma cells was observed, and CD133 and CD15 expression was compared between the normoxic and hypoxic groups.
[Journal of Cancer]
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The Opposing Action of Stromal Cell Proenkephalin and Stem Cell Transcription Factors in Prostate Cancer Differentiation

Researchers found that prostate cancer cells appeared to retain their responsiveness to stromal proenkephalin (PENK) signaling. PENK could induce differentiation to counter de-differentiation caused by stem cell transcription factor activation.
[BMC Cancer]
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Copper Depletion Modulates Mitochondrial Oxidative Phosphorylation to Impair Triple Negative Breast Cancer Metastasis

Using two independent TNBC models, the authors reported a discrete subpopulation of highly metastatic SOX2/OCT4+ cells within primary tumors that exhibitrf elevated intracellular copper levels and a marked sensitivity to tetrathiomolybdate.
[Nature Communications]
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Sox-Positive Cell Population in the Adult Cerebellum Increases upon Tissue Degeneration

A Bergmann glia population was analyzed in the adult cerebellum of different species and showed conservation of neural stem cell-associated marker expression including Sox1, Sox2 and Sox9, in chick, primate and mouse cerebellum tissue.
[Experimental Neurology]
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Metformin Promotes the Hair-Inductive Activity of Three-Dimensional Aggregates of Epidermal and Dermal Cells Self-Assembled In Vitro

Scientists assessed the effect of metformin on hair growth in a mouse hair follicle reconstitution model generated by in vitro self-assembled 3D aggregates of epidermal and dermal cells and suggested that metformin could promote hair follicle regeneration through up-regulation of the hair inductive capability of dermal cells.
[Skin Pharmacology and Physiology]
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Excellent Effects and Possible Mechanisms of Action of a New Antibody–Drug Conjugate against EGFR-Positive Triple-Negative Breast Cancer

Researchers evaluated the antitumor activities of LR004-VC-MMAE against epidermal growth factor receptor (EGFR)-positive TNBC and further studied its possible mechanism of antitumor action.
[Military Medical Research]
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