Sox2

[Stem Cell Research & Therapy] Researchers compared the cytoprotection between peritoneal dialysis (PD) effluent-derived MSCs and umbilical cord-derived MSCs in the treatment of both peritoneal membrane and kidney injury in uremic rats with chronic PD.

[Molecular Medicine Reports] M2‑like tumor‑associated macrophages (TAMs) accelerated the metastasis and increased the stemness of anaplastic thyroid carcinoma cells, and the underlying mechanism may have been related to the section of insulin‑like growth factor by M2‑like TAMs, which activated the IR‑A/IGF1R‑mediated PI3K/AKT/mTOR signaling pathway.

[Science Translational Medicine] Scientists reported that DNA-dependent protein kinase (DNA-PK) governed SOX2 stability through phosphorylation, resulting in glioma stem cell maintenance.

[Development] Scientists reported an organoid model of neural tube extension derived from human human PSC aggregates that had been caudalized with Wnt agonism, enabling them to recapitulate aspects of the morphological and temporal gene expression patterns of neural tube development.

[Neuroscience Letters] The authors investigated the differentiation capacity of human adult MSCs derived from adipose tissue into dopaminergic and neuron-like cells in the 3D culture plate.

[Experimental & Molecular Medicine] Investigators discuss the roles of the structural components of Oct proteins in reprogramming and how donor cell epigenomes endow Oct proteins with different reprogramming competences.