Rafael Pharmaceuticals Announces Successful Completion of Dose Escalation with No Dose-Limiting Toxicity (DLT) in First Cohort of APOLLO 613 Phase I/II Clinical Trial of CPI-613® (Devimistat) in Patients with Relapsed Clear Cell Sarcoma

Rafael Pharmaceuticals, Inc. announced the completion of the first cohort of dose escalation with no DLT in the APOLLO 613 Phase I/II clinical trial of devimistat in combination with hydroxychloroquine in patients with relapsed clear cell sarcoma.
[Rafael Pharmaceuticals, Inc. (Globe Newswire, Inc.)]
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Oncostatin M Can Sensitize Sensory Neurons in Inflammatory Pruritus

Researchers found that the cytokine oncostatin M was highly up-regulated in psoriasis, atopic dermatitis, and cutaneous T cell lymphoma, diseases associated with chronic itch.
[Science Translational Medicine]
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CD200 Expression in Hematopoietic Neoplasms: Beyond a Marker for Diagnosis of B Cell Neoplasms

Investigators review CD200 expression and its role in the immune evasion of non-B cell hematopoietic neoplasms and conclude that CD200 appears to be involved in the immune evasion of malignant cells, which could affect the survival of patients.
[Critical Reviews in Oncology Hematology]
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Antagonism of Inhibitors of Apoptosis Proteins Reveals a Novel, Immune-Based Therapeutic Approach for T-Cell Lymphoma

Researchers showed that tolinapant acted as an efficacious immunomodulatory molecule capable of inducing complete tumor regression in a syngeneic model of T cell lymphoma exclusively in the presence of an intact immune system.
[Blood Advances]
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Allogeneic Hematopoietic Stem Cell Transplantation from Unmanipulated Haploidentical Donor and Unrelated Cord Blood for T-cell Lymphoma: A Retrospective Study from the Société Francophone De Greffe De Moelle Et De Therapie Cellulaire

The authors evaluated the outcome of recipients of alternative donor allogeneic stem cell transplantation for T-cell lymphoma.
[Bone Marrow Transplantation]
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Multimodal Single-Cell Analysis of Cutaneous T Cell Lymphoma Reveals Distinct Sub-Clonal Tissue-Dependent Signatures

To identify and interrogate malignant clones in matched skin and blood from leukemic MF and SS patients, we combine T cell receptor clonotyping, with quantification of gene expression and cell surface markers at the single cell level.
[Blood]
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High-Dimensional and Single-Cell Transcriptome Analysis of the Tumor Microenvironment in Angioimmunoblastic T Cell Lymphoma (AITL)

Scientists utilized mass cytometry and single-cell transcriptome analysis to identify several expanded populations within the angioimmunoblastic T-cell lymphoma tumor microenvironment.
[Leukemia]
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A Novel lncRNA TCLlnc1 Promotes Peripheral T Cell Lymphoma Progression through Acting as a Modular Scaffold of HNRNPD and YBX1 Complexes

In this research, a novel lncRNA was identified overexpressed in the main subtypes of peripheral T cell lymphoma, and designated as T cell lymphoma-associated lncRNA1.
[Cell Death & Disease]
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FYN–TRAF3IP2 Induces NF-κB Signaling-Driven Peripheral T-Cell Lymphoma

Consistent with a driver oncogenic role, FYN–TRAF3IP2 expression in hematopoietic progenitors induced NF-κB-driven T-cell transformation in mice and cooperated with loss of the Tet2 tumor suppressor in peripheral T-cell lymphoma development.
[Nature Cancer]
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Combination of Anti-PD-1 Antibody with P-GEMOX as a Potentially Effective Immunochemotherapy for Advanced Natural Killer/T Cell Lymphoma

Scientists report the efficacy of anti-programmed death 1 antibody with the P-GEMOX (pegaspargase, gemcitabine, and oxaliplatin) regimen in advanced natural killer/T cell lymphoma.
[Signal Transduction and Targeted Therapy]
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Allogeneic Stem Cell Transplantation in Poor Prognosis Peripheral T-cell Lymphoma: The Impact of Different Donor Type on Outcome

Scientists report the outcome of 68 patients with advanced peripheral T-cell lymphoma receiving transplantation from haploidentical or from conventional donors. The four-year OS, PFS, 2-year cumulative incidence of relapse and 2-year GRFS was 75%, 70%, 21%, and 51%, respectively.
[Bone Marrow Transplantation]
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