T cells

[Trends in Cancer] Research on CD8+ T cell-dependent antitumor immunity has classically focused on its role in the primary tumor.

[Cancer Immunology Research] The authors showed that expression of the axon guidance molecule PlexinA4 in cytotoxic T cell, especially in effector/memory CD8+ T cells, was induced upon T cell activation, sustained in the circulation, but reduced when entering the tumor bed.

[Journal of Experimental Medicine] Scientists reported the high expression of acetyl-CoA carboxylase 1 in the pathogenic CD4+ T cell population in the lung and skin.

[Journal of Experimental Medicine] Using single-cell transcriptomics, researchers discovered a unique CD8 T cell blood/tumor-shared subpopulation in melanoma patients with high levels of oxidative phosphorylation (OXPHOS), the ectonucleotidases CD38 and CD39, and both exhaustion and cytotoxicity markers.

[Cell Reports] Researchers demonstrated that lymphoid-tissue-inducer-like ILC3s were enriched in the lung-draining lymph nodes of healthy mice and humans.

[Cancer Science] The authors investigated the anti-adult T cell leukemia/lymphoma effects of a novel oral HSP90 inhibitor TAS-116 and the mechanisms involved in ex vivo and in vivo preclinical models.