A High OXPHOS CD8 T Cell Subset Is Predictive of Immunotherapy Resistance in Melanoma Patients

Using single-cell transcriptomics, researchers discovered a unique CD8 T cell blood/tumor-shared subpopulation in melanoma patients with high levels of oxidative phosphorylation (OXPHOS), the ectonucleotidases CD38 and CD39, and both exhaustion and cytotoxicity markers.