T cells

[Stem Cell Reports] Scientists report successful targeting of the CCR5 locus in iPSCs generated from T cells or fibroblasts from Mauritian cynomolgus macaques, using CRISPR-Cas9 technology.

[OncoImmunology] Researchers characterized γδ T cell expansions from healthy adult donors and observe that highly potent natural killer lymphocytes expand with γδ T cells under zoledronate and IL-2 stimulation.

[Nature Communications] Investigators systematically dissected pancreatic ductal adenocarcinoma intrinsic mechanisms of immune evasion by in vitro and in vivo CRISPR screening, and identified Vps4b and Rnf31 as essential factors required for escaping CD8+ T cell killing.

[Cell Death & Disease] Researchers investigated the functional subsets of γδ T cells in hepatic fibrosis and to further explore the underlying causes and drivers of migration.

[Nature Communications] Scientists profiled 54,103 cells from tumor and adjacent tissues to characterize cellular composition and elucidated the potential origin and regulation of tumor-enriched cell types in colorectal cancer.

[Journal of Immunology] Scientists showed that IL-22+ T cells coexpressing retinoic acid–related orphan receptor γt were enriched at the human maternal-fetal interface of women with preterm labor and birth, which was confirmed by in silico analysis of single-cell RNA sequencing data.