Loss of Rnf31 and Vps4b Sensitizes Pancreatic Cancer to T Cell-Mediated Killing

Investigators systematically dissected pancreatic ductal adenocarcinoma intrinsic mechanisms of immune evasion by in vitro and in vivo CRISPR screening, and identified Vps4b and Rnf31 as essential factors required for escaping CD8+ T cell killing.