T cells

[Bioengineered] All hub genes were overexpressed in tumor tissue, and high expression of AURKB, CDC20, TPX2, and KIF2C correlated with the poor prognosis of non-small cell lung cancer patients. In vitro experiments confirmed that CDC20 knockdown inhibited cell proliferation and growth.

[IN8bio, Inc.] IN8bio, Inc. announced completion of dosing of the first patient cohort in a Phase I clinical trial of INB-100, a donor-derived gamma-delta T cell therapeutic in development for patients with leukemia undergoing haploidentical stem cell transplant.

[Scientific Reports] To evaluate the activation of Vγ9Vδ2 T cells by Lm-infected human monocyte-derived dendritic cells the authors engineered Lm strains that lacked components of the 2-C-methyl-D-erythritol 4- phosphate pathway.

[PLoS Pathogens] The authors interrogated the global transcriptional profile of isolated peripheral blood T cells before, during and after IFN-free DAA therapy using single-cell mRNA sequencing.

[Nature Communications] Scientists showed that human T cells engineered to express an mLPA-specific TCR, targeted diverse CD1c-expressing leukemia blasts in vitro and significantly delayed the progression of three models of leukemia xenograft in NSG mice, an effect that was boosted by mLPA-cellular immunization.

[Cellular & Molecular Immunology] The authors generated PD-1 and T cell receptor deficient mesothelin-specific CAR-T cells using CRISPR-Cas9 technology and evaluated them in a dose-escalation study.