Human T Cells Engineered with a Leukemia Lipid-Specific TCR Enables Donor-Unrestricted Recognition of CD1c-Expressing Leukemia

By
Justin.choi
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Scientists showed that human T cells engineered to express an mLPA-specific TCR, targeted diverse CD1c-expressing leukemia blasts in vitro and significantly delayed the progression of three models of leukemia xenograft in NSG mice, an effect that was boosted by mLPA-cellular immunization.
[Nature Communications]
Consonni, M., Garavaglia, C., Grilli, A., de Lalla, C., Mancino, A., Mori, L., De Libero, G., Montagna, D., Casucci, M., Serafini, M., Bonini, C., Häussinger, D., Ciceri, F., Bernardi, M., Mastaglio, S., Bicciato, S., Dellabona, P., & Casorati, G. (2021). Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia. Nature Communications, 12(1), 4844. https://doi.org/10.1038/s41467-021-25223-0 Cite
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