Longevity and Replenishment of Human Liver-Resident Memory T Cells and Mononuclear Phagocytes

Allografts were rapidly infiltrated by recipient leukocytes, which recapitulated the liver myeloid and lymphoid composition, and underwent partial reprogramming with acquisition of CD68/CD206 on MNPs and CD69/CD103 on T cells.
[Journal of Experimental Medicine]
[zotpress userid=’6445212′ items=’NX7LEV7′ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

Xenogenization of Tumor Cells by Fusogenic Exosomes in Tumor Microenvironment Ignites and Propagates Antitumor Immunity

Researchers suggested a previously unidentified method for xenogenizing tumors by using fusogenic exosomes to introduce fusogenic viral antigens onto the tumor cell surface.
[Science Advances]
[zotpress userid=’6445212′ items=’VZKU5KF’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Identification of Human CD4+ T Cell Populations with Distinct Antitumor Activity

Of clinical importance, CD26high and TH17 cells engineered with a chimeric antigen receptor regressed large human tumors to a greater extent than enriched TH1 or TH2 cells.
[Science Advances]
[zotpress userid=’6445212′ items=’SQAX9BEM’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

MCL-1 Is Essential for Survival but Dispensable for Metabolic Fitness of FOXP3+ Regulatory T Cells

Investigators elucidated the relative importance of these distinct biological functions of MCL-1 in T regulatory cells to assess whether MCL-1 inhibition might impact upon the metabolism of cells able to resist apoptosis.
[Cell Death & Differentiation]
[zotpress userid=’6445212′ items=’ZBSQW3EH’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

The SKI Proto-Oncogene Restrains the Resident CD103+CD8+ T Cell Response in Viral Clearance

The authors revealed a TGFβ–SKI–Smad4 pathway that critically and specifically directed resident CD103+CD8+ T cell generation for protective immunity against primary and secondary viral infection.
[Cellular & Molecular Immunology]
[zotpress userid=’6445212′ items=’ARYFP4NV’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

PRL3 Enhances T-Cell Acute Lymphoblastic Leukemia Growth through Suppressing T-Cell Signaling Pathways and Apoptosis

Scientists identified protein tyrosine phosphatase type 4 A3 (PRL3) as a collaborating oncogenic driver in T-cell acute lymphoblastic leukemia.
[Leukemia]
[zotpress userid=’6445212′ items=’QW9GQJZV’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

PD-L1+ Exosomes from Bone Marrow-Derived Cells of Tumor-Bearing Mice Inhibit Antitumor Immunity

Researchers report that exosomes from bone marrow-derived cells in tumor-bearing mice, but not in healthy mice, carried PD-L1. PD-L1 on these exosomes was biofunctional and could inhibit CD8+ T cell proliferation and activation in vitro and in vivo.
[Cellular & Molecular Immunology]
[zotpress userid=’6445212′ items=’IF6WZDT9′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Hypoxia-Inducible Factor-1: A Potential Pharmacological Target to Manage Psoriasis

Scientists discuss the evidence showing the crucial role of hypoxia-inducible factor-1α in psoriasis along with interrelationship with other mediators/signaling pathways that may contribute to the development of psoriasis.
[International Immunopharmacology]
[zotpress userid=’6630899′ items=’GZILGJDP’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Chd4 Choreographs Self-Antigen Expression for Central Immune Tolerance

Scientists found that the chromatin remodeler Chd4, also called Mi-2β, played a key role in the self-antigen expression in medullary thymic epithelial cells.
[Nature Immunology]
[zotpress userid=’6445212′ items=’LFA469L8′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Tumor Invasion in Draining Lymph Nodes Is Associated with Treg Accumulation in Breast Cancer Patients

Researchers studied regulatory T cells from matched tumor-invaded and non-invaded tumor-draining lymph node, and breast tumors.
[Nature Communications]
[zotpress userid=’6445212′ items=’78HQ9GRT’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Nurix Therapeutics Announces Formation of DeCART Therapeutics to Advance New CAR T Therapies Using Targeted Protein Modulation

Nurix Therapeutics, Inc. announced the formation of a new adoptive cell therapy company, DeCART Therapeutics, which has been initially formed as a wholly owned subsidiary of Nurix.
[Nurix Therapeutics, Inc.]
Bookmark

No account yet? Register

Share
Share