T cells

[Nature] Scientists identified mutation-associated neoantigens (MANA)-specific T cell clones using the MANA functional expansion of specific T cells assay3 in neoadjuvant anti-PD-1-treated non-small cell lung cancers.

[Nature Methods] The authors highlight advances in high-throughput sequencing technologies to identify TCR sequences and describe how they have been applied to discover fundamental insights into T cell-mediated immunity.

[Molecular Therapy-Methods & Clinical Development] Investigators found that high CD14+ cell content posed a challenge for manufacturing CAR T cells especially in patients with non-Hodgkin’s lymphoma and multiple myeloma due to the non-specific phagocytosis of the magnetic beads used to activate CD3+ T cells.

[Proceedings of the National Academy of Sciences of the United States of America] Leveraging the use of mass cytometry combined with multiplex major histocompatibility complex class I tetramer staining, researchers screened and identified tumor neoantigen–specific CD8+ T cells in the Lewis Lung carcinoma tumor model.

[Cell Reports] Genetic deletion or methylation of DNA-sensing/IFN genes or CCL5 chemokine was identified as a potential mechanism to attenuate T cell inflammation.

[Cell Reports] Using a model of dermal inflammation, investigators demonstrated that SPNS2 supplies the S1P that guided T cells out of lymph nodes with an ongoing immune response.