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T cells

Generation of Glucocorticoid-Resistant SARS-CoV-2 T Cells for Adoptive Cell Therapy

[Cell Host & Microbe] To assess the mechanisms contributing to protection, investigators analyzed humoral and T cell responses three weeks after a single BNT162b2 dose.

BATF Regulates Progenitor to Cytolytic Effector CD8+ T Cell Transition during Chronic Viral Infection

[Nature Immunology] The authors demonstrated that CX3CR1+ effector cells bear a striking similarity to short-lived effector cells during acute infection.

Castration-Mediated IL-8 Promotes Myeloid Infiltration and Prostate Cancer Progression

[Nature Cancer] Scientists established a novel mechanism by which castration mediated IL-8 secretion and subsequent polymorphonuclear myeloid-derived suppressor cells infiltration.

Single-Cell RNA-Seq Reveals Cellular Heterogeneity of Mouse Carotid Artery under Disturbed Flow

[Cell Death Discovery] Scientists investigated the heterogeneity of vascular cell populations under disturbed blood flow (d-flow). A d-flow-induced Spp1hi vascular smooth muscle cell subpopulation appeared to be endowed with osteoblast differentiation, suggesting a role in arterial stiffness.

Generation of Glucocorticoid-Resistant SARS-CoV-2 T Cells for Adoptive Cell Therapy

[Cell Reports] Scientists expanded SARS-CoV-2 T cells from the peripheral blood of COVID-19-recovered donors and non-exposed controls using different culture conditions.

Growth Arrest and DNA Damage-Inducible Proteins (GADD45) in Psoriasis

[Scientific Reports] Researchers analyzed the expression of GADD45a and GADD45b in the skin, dendritic cells and circulating T cells in a cohort of psoriasis patients and their regulation by inflammatory signals.

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