T cells

[Scientific Reports] Researchers investigated the effects of reducing the dose of posttransplantation cyclophosphamide (PTCy) followed by α-galactosylceramide, a ligand of iNKT cells, on the reciprocal balance between graft-versus-host disease (GVHD) and the graft-versus-leukemia (GVL) effect.

[Nature Communications] Using a transplantable mouse model of prostate carcinoma, scientists reported that tumor challenge leads to expansion of naïve neoantigen-specific CD8+ T cells and formation of a small population of non-recirculating tissue-resident memory T cells in several non-lymphoid tissues.

[Cell Reports] Delivery of regulatory macrophages (Mregs) completely abolished the priming of cognate CD8 cells and strongly reduced delayed-type hypersensitivity reactions. Mreg-mediated T cell suppression requires cell-cell contact-regulated nitric oxide production.

[Genome Biology] By analyzing inducible gene-disrupted mice, researchers showed that DNA demethylation during primary T cell differentiation occured mainly through passive replication-dependent dilution of all three oxi-mCs, with only a negligible contribution from DNA glycosylase.

[JCI Insight] Investigators showed that macrophages contributed significantly to the loss of β-cells and the subsequent development of hyperglycemia. Depletion or inhibition of 12-LOX in this model resulted in reduced macrophage infiltration into islets and the preservation of β-cell mass.

[Nature Biomedical Engineering] The authors showed in multiple murine tumor models that inulin-a widely consumed dietary fiber-formulated as a ‘colon-retentive’ orally administered gel could effectively modulate the gut microbiome in situ, induced systemic memory-T-cell responses and amplified the antitumour activity of the checkpoint inhibitor anti-programmed cell death protein-1.