Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsBy analyzing inducible gene-disrupted mice, researchers showed that DNA demethylation during primary T cell differentiation occured mainly through passive replication-dependent dilution of all three oxi-mCs, with only a negligible contribution from DNA glycosylase.
[Genome Biology]
6445212 3VDRNSSE items 1 apa 0 default asc 1 163860 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-ba8ef2f276c0e18182fd3edf1a457bbf%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%223VDRNSSE%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Onodera%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-22%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EOnodera%2C%20A.%2C%20Gonz%26%23xE1%3Blez-Avalos%2C%20E.%2C%20Lio%2C%20C.-W.%20J.%2C%20Georges%2C%20R.%20O.%2C%20Bellacosa%2C%20A.%2C%20Nakayama%2C%20T.%2C%20%26amp%3B%20Rao%2C%20A.%20%282021%29.%20Roles%20of%20TET%20and%20TDG%20in%20DNA%20demethylation%20in%20proliferating%20and%20non-proliferating%20immune%20cells.%20%3Ci%3EGenome%20Biology%3C%5C%2Fi%3E%2C%20%3Ci%3E22%3C%5C%2Fi%3E%281%29%2C%20186.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13059-021-02384-1%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13059-021-02384-1%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3D3VDRNSSE%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Roles%20of%20TET%20and%20TDG%20in%20DNA%20demethylation%20in%20proliferating%20and%20non-proliferating%20immune%20cells%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Atsushi%22%2C%22lastName%22%3A%22Onodera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edah%5Cu00ed%22%2C%22lastName%22%3A%22Gonz%5Cu00e1lez-Avalos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chan-Wang%20Jerry%22%2C%22lastName%22%3A%22Lio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%20O.%22%2C%22lastName%22%3A%22Georges%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alfonso%22%2C%22lastName%22%3A%22Bellacosa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Toshinori%22%2C%22lastName%22%3A%22Nakayama%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anjana%22%2C%22lastName%22%3A%22Rao%22%7D%5D%2C%22abstractNote%22%3A%22TET%20enzymes%20mediate%20DNA%20demethylation%20by%20oxidizing%205-methylcytosine%20%285mC%29%20in%20DNA%20to%205-hydroxymethylcytosine%20%285hmC%29%2C%205-formylcytosine%20%285fC%29%2C%20and%205-carboxylcytosine%20%285caC%29.%20Since%20these%20oxidized%20methylcytosines%20%28oxi-mCs%29%20are%20not%20recognized%20by%20the%20maintenance%20methyltransferase%20DNMT1%2C%20DNA%20demethylation%20can%20occur%20through%20%5Cu201cpassive%2C%5Cu201d%20replication-dependent%20dilution%20when%20cells%20divide.%20A%20distinct%2C%20replication-independent%20%28%5Cu201cactive%5Cu201d%29%20mechanism%20of%20DNA%20demethylation%20involves%20excision%20of%205fC%20and%205caC%20by%20the%20DNA%20repair%20enzyme%20thymine%20DNA%20glycosylase%20%28TDG%29%2C%20followed%20by%20base%20excision%20repair.%22%2C%22date%22%3A%22June%2022%2C%202021%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs13059-021-02384-1%22%2C%22ISSN%22%3A%221474-760X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13059-021-02384-1%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-23T17%3A25%3A58Z%22%7D%7D%5D%7D
Onodera, A., González-Avalos, E., Lio, C.-W. J., Georges, R. O., Bellacosa, A., Nakayama, T., & Rao, A. (2021). Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells. Genome Biology, 22(1), 186. https://doi.org/10.1186/s13059-021-02384-1 Cite
