12-Lipoxygenase Governs the Innate Immune Pathogenesis of Islet Inflammation and Autoimmune Diabetes

By
Justin.choi
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Investigators showed that macrophages contributed significantly to the loss of β-cells and the subsequent development of hyperglycemia. Depletion or inhibition of 12-LOX in this model resulted in reduced macrophage infiltration into islets and the preservation of β-cell mass.
[JCI Insight]
Kulkarni, A., Pineros, A. R., Walsh, M. A., Casimiro, I., Ibrahim, S., Hernandez-Perez, M., Orr, K. S., Glenn, L., Nadler, J. L., Morris, M. A., Tersey, S. A., Mirmira, R. G., & Anderson, R. M. (2021). 12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes. JCI Insight. https://doi.org/10.1172/jci.insight.147812 Cite
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