T cells

[Nature Immunology] Interruption of T cell antigen receptors-mediated ‘normality sensing’ had no impact on γδ T cell numbers but altered their signature phenotype, while the epidermal barrier function was compromised.

[Carcinogenesis] Scientists indicated that intermittently blocking TCR signal by tacrolimus could promote anti-tumor immunity and inhibit the tumor growth in melanoma-bearing mice, inhibiting the transcription of several exhaustion-related genes, such as Nr4a1 and Ctla4.

[Frontiers in Immunology] Investigators explored the impact of epigenetic modifiers and differentiation agents on leukemia cell lines of B cell origin, as well as normal B cells.

[Genome Biology] The authors used R2C2 to sequence and demultiplex 12 million full-length cDNA molecules generated by the 10X Genomics platform from ~3000 peripheral blood mononuclear cells.

[PLoS Biology] Scientists found that in primary human memory T helper lymphocytes, miR-150 was the most abundantly expressed miRNA, and its expression decreased drastically upon activation, suggesting regulatory roles.

[Journal of Clinical Investigation] Investigators reported that SUMO-specific protease 7 sensed oxidative stress to maintain the CD8+ T cell metabolic state and antitumor functions.