T cells

[Cell Reports] The authors probed the heterogeneity present among naive CD4+ T cells before encountering their cognate antigen to ask whether their effector potential was modulated by pre-existing transcriptional and chromatin landscape differences.

[Science Translational Medicine] The authors investigated the impact of repeated P. falciparum infections on human γδ T cells in the context of natural infection in Malian children and adults, as well as serial controlled human malaria infection of US adults, some of whom became clinically immune to malaria.

[Cellular & Molecular Immunology] Investigators review the key findings that have shaped our understanding of how immune cells regulate adipose tissue homeostasis to control organismal metabolism.

[eLife] Scientists showed that histone deacetylase 3 was critical for activation of murine peripheral CD4+ T cells.

[Nature] Investigators defined a population of inflammatory group 3 innate lymphoid cells that infiltrate the central nervous system in a mouse model of multiple sclerosis.

[Immunity] The composition of the intestinal microbiota is associated with both the development of tumors and the efficacy of anti-tumor immunity. Researchers examined the impact of microbiota-specific T cells in anti-colorectal cancer immunity.