FOXP3 Activated-LINC01232 Accelerates the Stemness of Non-Small Cell Lung Carcinoma by Activating TGF-β Signaling Pathway and Recruiting IGF2BP2 to Stabilize TGFBR1

Flow cytometry and sphere formation assays indicated that LINC01232 significantly promoted non-small cell lung carcinoma cell stemness.
[Experimental Cell Research]
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SMURF2 Phosphorylation at Thr249 Modifies Glioma Stemness and Tumorigenicity by Regulating TGF-β Receptor Stability

Researchers demonstrated that SMAD specific E3 ubiquitin protein ligase 2 (SMURF2)Thr249 phosphorylation played an essential role in maintaining glioma stem cell (GSC) stemness and tumorigenicity. SMURF2 silencing augmented the self-renewal potential and tumorigenicity of patient-derived GSCs.
[Communications Biology]
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The KRAS-Regulated Kinome Identifies WEE1 and ERK Co-Inhibition as a Potential Therapeutic Strategy in KRAS-Mutant Pancreatic Cancer

Investigtors established a system-wide profile of the KRAS-regulated kinase signaling network in KRAS-mutant pancreatic ductal adenocarcinoma.
[Journal of Biological Chemistry]
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M6A RNA Methylation-Mediated RMRP Stability Renders Proliferation and Progression of Non-Small Cell Lung Cancer through Regulating TGFBR1/SMAD2/SMAD3 Pathway

Based on an integrative analysis of The Cancer Genome Atlas database, investigators identified long non-coding RNA-RNA Component of Mitochondrial RNA Processing Endoribonuclease (RMRP) as one of the most highly upregulated lncRNAs that are associated with poor survival in non-small cell lung cancer.
[Cell Death & Differentiation]
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ZNF507 Affects TGF-β Signaling via TGFBR1 and MAP3K8 Activation in the Progression of Prostate Cancer to an Aggressive State

The authors identified the novel transcriptional factor ZNF507 as a key mediator in the progression of prostate cancer to an aggressive state.
[Journal of Experimental & Clinical Cancer Research]
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Exosomes Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells Stimulate Regenerative Wound Healing via Transforming Growth Factor-β Receptor Inhibition

To determine the function of umbilical cord blood (UCB)-MSCs, scientists examined and compared the therapeutic effects of UCB-MSCs and UCB-MSC-derived exosomes on skin healing in rats.
[Stem Cell Research & Therapy]
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A Novel lncRNA TCLlnc1 Promotes Peripheral T Cell Lymphoma Progression through Acting as a Modular Scaffold of HNRNPD and YBX1 Complexes

In this research, a novel lncRNA was identified overexpressed in the main subtypes of peripheral T cell lymphoma, and designated as T cell lymphoma-associated lncRNA1.
[Cell Death & Disease]
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Fibroblast-Enriched Endoplasmic Reticulum Protein TXNDC5 Promotes Pulmonary Fibrosis by Augmenting TGFβ Signaling through TGFBR1 Stabilization

Mechanistic investigations demonstrated that thioredoxin domain containing 5 (TXNDC5) promotes fibrogenesis by enhancing TGFβ1 signaling through direct binding with and stabilization of TGFBR1 in lung fibroblasts.
[Nature Communications]
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