VEGF

[Oxidative Medicine and Cellular Longevity] In order to discover novel endothelial-specific receptor tyrosine kinases (VEGFR)-2 TK inhibitors, scientists designed and synthesized three new series of pyridine-containing compounds. The new compounds were all screened against a panel of three cell lines.

[British Journal of Cancer] A colorectal cancer cohort was analyzed to determine whether DP1 and DP2 receptor expression correlated with patient survival.

[Chemico-Biological interactions] The authors found that 1,3-diphenyl-2-benzyl-1,3-propanedione (DPBP) had high in vitro antineoplastic activity against murine B16F10 melanoma cells and used transdermal and topical formulations of DPBP to evaluate its activity in a murine model of melanoma.

[Experimental Eye Research] Scientists showed that pigment epithelium derived factor (PEDF) prevented early mitogenic signals of vascular endothelial growth factor in primate retinal endothelial cells, blocking proliferation, migration and tube formation.

[Advanced Materials] Scientists reported a nanomicelle drug delivery system made of a co-polymer endothelial progenitor cells, which was capable of delivering aflibercept to the posterior segment topically through corneal-scleral routes.

[Journal of Materials Science-Materials in Medicine] The authors investigated whether cardiomyocytes culturing on cardiac aorta-derived extracellular matrix scaffold had advantageous effects on cardiomyocytes survival and angiogenesis biomarkers’ expression.