VEGF

[Journal of Cancer Research and Clinical Oncology] Scientists summarize recent advancements of 3D tumor vascular model systems which include tissue engineering-based tumor models; vascular organoid models, and organ-on-chips and their importance in replicating the tumor angiogenesis along with the associated challenges to design improved models.

[Journal of Cellular and Molecular Medicine] Liver SMAD2 phosphorylation was down-regulated in all series with matrix metalloproteinase (MMP) inhibition or knock-out, and MMP-9 inhibition or deletion ameliorated the severity of cirrhosis, portal hypertension, and associated derangements.

[Biomedical Materials] The authors demonstrated that the proliferation of keratinocytes and their secretion of cytokines and growth factors could be activated through appropriate electrical stimulation to benefit skin wound healing.

[Journal of Cardiovascular Pharmacology] Researchers found that NAMPT overexpression protected human coronary artery endothelial cells from H2O2-induced injury through promoting cell viability, inhibiting cell apoptosis, enhancing cell motility, and promoting tube formation.

[Scientific Reports] The authors evaluated enhanced therapeutic effects of tonsil-derived mesenchymal stem cells on a murine colitis model using 3D culture method.

[Oncology Reports] The authors investigated the effect of tinzaparin on VL30 retrotransposition‑positive mouse HC11 mammary stem‑like epithelial cells, previously reported to be associated with induced mammosphere/cancer stem cell (CSC) generation and tumorigenesis.