VEGF

[Nature Cell Biology] Oxidation of CTR1 at Cys189 promoted VEGFR2 internalization and signaling to enhance angiogenesis. Scientists uncovered an important mechanism for sensing reactive oxygen species through CTR1 to drive neovascularization.

[REGENXBIO, Inc.] REGENXBIO, Inc. announced the initiation of ASCENTTM, the second of two Phase III pivotal trials to evaluate the efficacy and safety of subretinal delivery of RGX-314 in patients with wet age-related macular degeneration (wet AMD).

[Stem Cell Research & Therapy] The authors investigated the therapeutic effect of human amniotic MSCs combined with polyethylene glycol citrate-co-N-isopropylacrylamide mixed with gelatin (PPCNg) transplantation in promoting the regeneration of injured endometrium.

[Scientific Reports] Investigators evaluated the potential of combining a natural and accessible biomaterial based on platelet poor plasma as a support for dental pulp stem cells and umbilical cord MSCs.

[Journal of the American Chemical Society] Investigators established a robust synthesis method for faceted nanoceria with primary particle diameters of 5–6 nm. The nanoceria were not cytotoxic to a human melanoma cell line at doses up to 400 μg/mL and were dose-dependently internalized by the cells.

[Theranostics] Researchers reported on non-invasive longitudinal imaging of the wound healing process in transgenic mice overexpressing vascular endothelial growth factor (VEGF) A in keratinocytes by means of large-scale optoacoustic microscopy.