Cysteine Oxidation of Copper Transporter CTR1 Drives VEGFR2 Signaling and Angiogenesis

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Oxidation of CTR1 at Cys189 promoted VEGFR2 internalization and signaling to enhance angiogenesis. Scientists uncovered an important mechanism for sensing reactive oxygen species through CTR1 to drive neovascularization.
[Nature Cell Biology]
Abstract