YAP

[Stem Cells and Development] Compared with tumor-adjacent normal tissues, death-associated protein kinase 1 (DAPK1) expression was reduced in prostate cancer cell lines with respect to that in normal prostate cells.

[Developmental Cell] The authors demonstrated that human PSC fate was coupled to mechanical cues imposed by neighboring cells and revealed that hijacking this mechanism allowed variants to achieve clonal dominance in cultures.

[iScience] Postnatal YAP activation increased epithelial cell proliferation, increased alveolar type-1 cell numbers, and caused indeterminate differentiation of subsets of alveolar cells expressing atypical genes normally restricted to airway epithelial cells.

[Cell Death Discovery] Investigators explored the relationship bewteen ursodeoxycholic acid (UDCA) and YAP in colorectal cancer (CRC) and found that the restoration of YAP expression alleviated the inhibitory effect of UDCA on CRC cell proliferation.

[Free Radical Biology and Medicine] Scientists chose a panel of PDAC cell lines with diverse sensitivity to cisplatin and gemcitabine. In PANC-1 chemoresistant cells, they found a low level of oxidative stress and high levels of Nrf2 and YAP protein expressions and their respective targets.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers identified an important role for uridine diphosphate-glucose pyrophosphorylase 2 in the maintenance of pancreatic ductal adenocarcinoma growth in both in vitro and in vivo tumor models.