YAP

[Nature Communications] Using a high-throughput phenotypic screen, scientists identified a potent and non-toxic activator of Yap. In vitro kinase assays show that the compound acts as an ATP-competitive inhibitor of Lats kinases-the core enzymes in Hippo signaling.

[Scientific Reports] Researchers leveraged adeno-associated virus (AAV) to target cardiac fibroblasts and demonstrated that chronic Yes-associated protein (YAP) expression upregulated indices of fibrosis and inflammation in the absence of additional stress.

[Scientific Reports] Investigators identified and elucidated the function of a miR-375/yes-associated protein axis in lung carcinoid (H727) cells.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers developed a spatial model of YAP/TAZ translocation to enable quantitative analysis of the relationships between substrate stiffness, substrate dimensionality, and cell shape.

[Molecular Therapy] Researchers found that simvastatin inhibited PD-L1 expression and promoted anti-tumor immunity via suppressing the expression of lncRNA SNHG29.

[Scientific Reports] Scientists investigated yes-associated protein (YAP) activity using disease-specific induced pluripotent stem cell derived cardiomyocytes in Duchenne muscular dystrophy.