YAP

[Connective Tissue Research] The protein level of insulin-like growth factor 1 receptor (IGF-1 R), detected as the upstream molecule of Yes-associated protein (YAP), was reduced in the INS-1 cells cultured on the dishes coated with collagen V.

[Oncogene] Researchers identified a key regulator of macropinocytosis for the survival of tumor cells in a low amino acid environment in pancreatic ductal adenocarcinoma.

[Cell Stem Cell] Scientists profiled scarring versus YAP-inhibition-induced wound regeneration at the transcriptional, protein, and tissue levels, and showed that disrupting YAP mechanotransduction yielded regenerative repair by fibroblasts with activated Trps1 and Wnt signaling.

[Nature Reviews Gastroenterology & Hepatology] The authors summarize the diverse roles of Hippo signaling in liver biology and highlight areas where outstanding questions remain to be investigated.

[Scientific Reports] Researchers described a possible mechanism involved in skin aging focusing on the effect of Trehangelins on epidermal cellular communication metwork factor 1 (CCN1).

[Cell Death & Disease] Scientists found that the low expression of RICH1 in breast cancer was associated with poor prognosis. Depletion of RICH1 promoted the stemness and disrupted the normal epithelial architecture of MCF10A cells.