YAP

[Oncogene] Investigators showed that endothelial-to-osteoblast (EC-to-OSB) transition led to changes in the tumor microenvironment that increased the metastatic potential of prostate cancer (PCa) cells. They found that conditioned medium from EC-OSB hybrid cells increased the migration and survival of PC3-mm2 and C4-2B4 PCa cells.

[Chemico-Biological interactions] Researchers investigated the role of components of the Hippo signaling pathway for E-cadherin-mediated contact inhibition of proliferation in the lungs after air pollution exposure.

[Molecular Carcinogenesis] Scientists found that NUAK family kinase 2 (NUAK2) expression was elevated in prostate cancer and metastatic castration resistant PC versus normal tissue, and expression correlated with an increased risk of metastasis.

[Nature Communications] Researchers showed that loss of ABHD5 promoted c-Met activation to sustain colorectal cancer stemness in a non-canonical manner.

[Nature Communications] Scientists showed that smooth muscle cells might be the dominant suppliers of BMP antagonists, which are niche factors essential for intestinal stem cell maintenance.

[Journal of Hepatology] Scientists investigated the role of Sox9, a transcription factor downstream of Yap activation and expressed in biliary epithelial cells (BECs), in Yap-induced cell fate plasticity during hepatocarcinogenesis.