Prostate Tumor-Induced Stromal Reprogramming Generates Tenascin C That Promotes Prostate Cancer Metastasis through YAP/TAZ Inhibition

Investigators showed that endothelial-to-osteoblast (EC-to-OSB) transition led to changes in the tumor microenvironment that increased the metastatic potential of prostate cancer (PCa) cells. They found that conditioned medium from EC-OSB hybrid cells increased the migration and survival of PC3-mm2 and C4-2B4 PCa cells.