acute myeloid leukemia

[Blood] To target CD70 on acute myeloid leukemia cells, researchers generated a panel of CD70-CAR T cells that contained a common single-chain variable fragment for antigen detection, but differed in size and flexibility of the extracellular spacer and in the transmembrane and the costimulatory domains.

[BMC Medicine] Patients’ gene expression profile from seven GEO databases was normalized after removing the batch effect. Tumor immune microenvironment (TIME) cell components were explored through Xcell tools and then hierarchically clustered to establish TIME classification.

[Molecular Cell] ZMYND8 was essential for acute myeloid leukemia proliferation in vitro and in vivo and associated with MYC and IRF8 enhancer elements that researchers defined in cell lines and in patient samples.

[Leukemia] Treatment of human acute myeloid leukemia (AML) cells with a PAICS inhibitor suppressed their proliferation by inhibiting DNA synthesis and promoting apoptosis and had anti-leukemic effects in AML PDX models.

[Annals of Hematology] Scientists investigated the effect of ZEN-3365, a novel BRD4 inhibitor, on acute myeloid leukemia cells in regard to the Hedgehog pathway.

[Leukemia] Researchers presented a strategy to target mutated JAK2 for degradation, using the cell’s intracellular degradation machinery, while sparing non-mutated JAK2, and found that targeting JOSD1 led to the death of JAK2-V617F-positive primary acute myeloid leukemia cells.