alcoholic liver disease

[Cell Proliferation] Investigators summarize the recent progress on the roles and mechanisms of necroptosis and focus on the crosstalk between necroptosis and the other pathogenesis of alcoholic liver disease (ALD), providing a theoretical basis for targeting necroptosis as a novel treatment for ALD.

[Cell Discovery] Liver-specific Sirutin 2 (SIRT2) deficiency sensitized mice to alcoholic liver disease, whereas transgenic SIRT2 overexpression in hepatocytes significantly prevented ethanol-induced liver injury via normalization of hepatic steatosis, lipid peroxidation, and hepatocyte apoptosis.

[Cell Death Discovery] The authors review recent progress of ferroptosis studies delineating molecular mechanisms underlying the pathophysiology of several common liver diseases including ischemia/reperfusion-related injury, nonalcoholic fatty liver disease, alcoholic liver disease, hemochromatosis, drug-induced liver injury, and hepatocellular carcinoma.

[Cell Biology and Toxicology] Pterostilbene is a natural compound with hepatoprotective potential; however, its implication for alcoholic liver disease was not understood. Scientists investigated the therapeutic effect of pterostilbene on alcoholic liver disease and elucidate the potential mechanism.

[Laboratory Investigation] Investigators demonstrated that PTGIS was downregulated in alchoholic liver disease and forced PTGIS expression in vivo using recombinant adeno-associated viral vector-packed prostacyclin synthase overexpression plasmid, which alleviated the inflammatory response and suppressed the macrophage M1 phenotype in mice.

[Cellular & Molecular Immunology] Scientists review the roles of multiple immunological mechanisms and therapeutic targets related to the inflammation associated with fatty liver diseases and the differences in the progression of alcoholic liver disease and nonalcoholic fatty liver disease. Multiple cell types in the liver, including macrophages, neutrophils, other immune cell types and hepatocytes, are involved in fatty liver disease inflammation.