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Pulmonary Cell NewsInvestigators demonstrated that PTGIS was downregulated in alchoholic liver disease and forced PTGIS expression in vivo using recombinant adeno-associated viral vector-packed prostacyclin synthase overexpression plasmid, which alleviated the inflammatory response and suppressed the macrophage M1 phenotype in mice.
[Laboratory Investigation]
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Pan, X., Wang, L., You, H., Cheng, M., Yang, Y., Huang, C., & Li, J. (2021). Alternative activation of macrophages by prostacyclin synthase ameliorates alcohol induced liver injury. Laboratory Investigation, 1–15. https://doi.org/10.1038/s41374-021-00531-7 Cite
