aplastic anemia

[Stem Cells Translational Medicine] The authors designed a combination of haplo‐hematopoietic stem cells transplantation with allogenic mesenchymal stem cells for treatment of severe aplastic anemia in pediatric and adolescent patients and evaluated its effects.

[Clinical Epigenetics] Researchers analyzed blood samples of 70 aplastic anemia (AA) and 18 dyskeratosis congenita (DKC) patients to demonstrate that their epigenetic age predictions were overall increased, albeit not directly correlated with telomere length. Aberrant DNA methylation was observed in the gene PRDM8 in DKC and AA as well as in other diseases with premature aging phenotype, such as Down syndrome and Hutchinson-Gilford-Progeria syndrome.

[Biology of Blood and Marrow Transplantation] Researchers retrospectively analyzed the outcomes of 214 severe aplastic anemia patients who underwent allogeneic hematopoietic stem cell transplantation with r-ATG or ATG-Fresenius.

[European Journal of Haematology] Investigators report the first case of an adult patient with severe aplastic anemia who was successfully transplanted with a UM171‐expanded cord blood graft. After a conditioning of rabbit anti‐thymocyte globulin, fludarabine, cyclophosphamide and total body irradiation, a UM171 expanded graft of 3.29 x 106 CD34+ cells/kg was infused.