PRDM8 Reveals Aberrant DNA Methylation in Aging Syndromes and Is Relevant for Hematopoietic and Neuronal Differentiation

Researchers analyzed blood samples of 70 aplastic anemia (AA) and 18 dyskeratosis congenita (DKC) patients to demonstrate that their epigenetic age predictions were overall increased, albeit not directly correlated with telomere length. Aberrant DNA methylation was observed in the gene PRDM8 in DKC and AA as well as in other diseases with premature aging phenotype, such as Down syndrome and Hutchinson-Gilford-Progeria syndrome.