Investigators report the first case of an adult patient with severe aplastic anemia who was successfully transplanted with a UM171‐expanded cord blood graft. After a conditioning of rabbit anti‐thymocyte globulin, fludarabine, cyclophosphamide and total body irradiation, a UM171 expanded graft of 3.29 x 106 CD34+ cells/kg was infused.
[European Journal of Haematology]
6445212 {6445212:CXB3QJJY} apa 50 1 152605 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-d4aee114dfabe2d7cb604e16267e8fa8%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22CXB3QJJY%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Claveau%20et%20al.%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EClaveau%2C%20J.-S.%2C%20Cohen%2C%20S.%2C%20Ahmad%2C%20I.%2C%20Delisle%2C%20J.-S.%2C%20Kiss%2C%20T.%2C%20Lachance%2C%20S.%2C%20Sauvageau%2C%20G.%2C%20Busque%2C%20L.%2C%20Brito%2C%20R.-M.%2C%20Bambace%2C%20N.%2C%20Bernard%2C%20L.%2C%20Roy%2C%20D.%20C.%2C%20%26amp%3B%20Roy%2C%20J.%20%28n.d.%29.%20Single%20UM171-expanded%20cord%20blood%20transplant%20can%20cure%20severe%20idiopathic%20aplastic%20anemia%20in%20absence%20of%20suitable%20donors.%20%3Ci%3EEuropean%20Journal%20of%20Haematology%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fejh.13504%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fejh.13504%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DCXB3QJJY%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Single%20UM171-expanded%20cord%20blood%20transplant%20can%20cure%20severe%20idiopathic%20aplastic%20anemia%20in%20absence%20of%20suitable%20donors%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-S%5Cu00e9bastien%22%2C%22lastName%22%3A%22Claveau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%22%2C%22lastName%22%3A%22Cohen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Imran%22%2C%22lastName%22%3A%22Ahmad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-S%5Cu00e9bastien%22%2C%22lastName%22%3A%22Delisle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Kiss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Silvy%22%2C%22lastName%22%3A%22Lachance%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Sauvageau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lambert%22%2C%22lastName%22%3A%22Busque%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rose-Marie%22%2C%22lastName%22%3A%22Brito%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Bambace%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%5Cu00e9a%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%20Claude%22%2C%22lastName%22%3A%22Roy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Roy%22%7D%5D%2C%22abstractNote%22%3A%22Haplo-identical%20donors%20have%20been%20increasingly%20used%20as%20an%20alternative%20source%20of%20stem%20cells%20in%20patients%20with%20severe%20aplastic%20anemia%20in%20need%20of%20an%20allogeneic%20transplantation%20but%20lack%20a%20matched%20donor.%20Single%20cord%20blood%20%28CB%29%20transplant%20also%20offers%20a%20curative%20option%20for%20this%20disease%20but%20few%20adult%20patients%20have%20been%20reported%20due%20to%20low%20number%20of%20progenitor%20cells%20leading%20to%20prolonged%20cytopenias%20and%20a%20high%20risk%20of%20infections.%20CB%20stem%20cell%20expansion%20may%20theoretically%20solve%20these%20pitfalls%20but%20has%20not%20been%20used%20previously%20in%20non%20malignant%20diseases%2C%20likely%20due%20to%20fear%20of%20graft%20rejection%20and%20lack%20of%20availability%20of%20expanded%20CBs%20outside%20clinical%20trials%20.%20We%20report%20the%20first%20case%20of%20an%20adult%20patient%20with%20severe%20aplastic%20anemia%20who%20was%20successfully%20transplanted%20with%20a%20UM171-expanded%20CB%20graft.%20After%20a%20conditioning%20of%20rabbit%20anti-thymocyte%20globulin%2C%20fludarabine%2C%20cyclophosphamide%20and%20total%20body%20irradiation%2C%20a%20UM171%20expanded%20graft%20of%203.29%20x%20106%20CD34%2B%20cells%5C%2Fkg%20%28a%2051%20fold%20increase%29%20was%20infused.%20Full%20donor%20chimerism%20was%20observed%20on%20day%20%2B14%2C%20with%20neutrophil%20and%20platelet%20engraftment%20on%20day%20%2B23%20and%20%2B27.%20There%20was%20no%20severe%20infection%20or%20graft-versus-host%20disease.%20UM171-expanded%20grafts%20offer%20a%20valuable%20option%20for%20patients%20with%20aplastic%20anemia%20in%20need%20of%20transplantation%20but%20have%20no%20suitable%20donor.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1111%5C%2Fejh.13504%22%2C%22ISSN%22%3A%221600-0609%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1111%5C%2Fejh.13504%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222020-08-05T21%3A43%3A51Z%22%7D%7D%5D%7D
Claveau, J.-S., Cohen, S., Ahmad, I., Delisle, J.-S., Kiss, T., Lachance, S., Sauvageau, G., Busque, L., Brito, R.-M., Bambace, N., Bernard, L., Roy, D. C., & Roy, J. (n.d.). Single UM171-expanded cord blood transplant can cure severe idiopathic aplastic anemia in absence of suitable donors. European Journal of Haematology, n/a(n/a). https://doi.org/10.1111/ejh.13504 Cite