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apoptosis assay

An Oral First-in-Class Small Molecule RSK Inhibitor Suppresses AR Variants and Tumor Growth in Prostate Cancer

[Cancer Science] Scientists investigated the effect of PMD-026 on YB-1/AR signaling and its antitumor effect in prostate cancer in vitro and in vivo and demonstrated an excellent antitumor effect of the novel ribosomal S6 kinase inhibitor PMD-026 and the combination effect with the antiandrogen enzalutamide in CRPC.

The Inhibitory Effect of LINC00261 Upregulation on the Pancreatic Cancer EMT Process Is Mediated by KLF13 via the mTOR Signaling Pathway

[Clinical and Translational Oncology] The location of LINC00261 in PC cells was identified by RNA fluorescence in situ hybridization (RNA-FISH).

Diosmin in Combination with Naringenin Enhances Apoptosis in Colon Cancer Cells

[Oncology Reports] The combined effect of Diosmin and naringenin in colon cancer cell lines HCT116 and SW480 were assessed by targeting apoptosis and inflammatory pathways.

High-Throughput Compound Screening Identifies Navitoclax Combined with Irradiation as a Candidate Therapy for HPV-Negative Head and Neck Squamous Cell Carcinoma

[Scientific Reports] Scientists ran an assay using five human papillomavirus (HPV)-negative head and neck squamous cell carcinoma cell lines cultured on the human tumor-derived matrix Myogel.

Nitidine Chloride Suppresses NEDD4 Expression in Lung Cancer Cells

[Aging] The authors aimed to determine the biological effect of nitidine chloride (NC) and the underlying molecular insights in lung cancer cells. The antineoplastic function of NC was assessed by MTT assays, Annexin V-FITC/PI apoptosis assay, wound healing analysis, and Transwell chamber migration and invasion assay in lung cancer cells.

Annexin-A1 Promotes RIG-I-Dependent Signaling and Apoptosis via Regulation of the IRF3–IFNAR–STAT1–IFIT1 Pathway in A549 Lung Epithelial Cells

[Cell Death & Disease] Researchers explored the role of Annexin A1 (ANXA1) in Influenza Type A viruses infection of A549 lung epithelial cells further in the context of RIG-I-dependent signaling using A549 and Crispr/Cas9 ANXA1 deleted cells

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