asthma

[Journal of Clinical Immunology] Scientists collected clinical histories of 13 patients with IL-21R deficiency from eight families across seven centers worldwide, including five novel patients identified by exome or NGS panel sequencing.

[Journal of Clinical Investigation] Researchers showed that another member of the integrin superfamily, integrin α2β1, was present in airway smooth muscle and capable of regulating force transmission via cellular tethering to the matrix protein collagen I, and to a lesser degree, laminin-111.

[Angiogenesis] The authors highlight the phenotype and function of high endothelial venules (HEVs) in homeostatic, inflamed and tumor-draining lymph nodes, and those of HEV-like blood vessels in chronic inflammatory diseases.

[Laboratory Investigation] Researchers investigated the molecular mechanism of enhancer of zeste homolog 2 (EZH2) in the development of asthma.

[Nature Communications] CD200R engagement inhibited activation, proliferation and type 2 cytokine production, indicating an immunoregulatory function for the CD200–CD200R axis on Group 2 innate lymphoid cells.

[Journal of Autoimmunity] The authors evaluate the development of (autoreactive) T cells and their response to (auto)antigens, as well as the role of the peripheral tolerance in autoimmunity in the pathophysiology of atopic dermatitis (AD), including the unmet needs and gaps.