asthma

[American Journal of Human Genetics] Researchers systematically applied Mendelian randomization, genetic colocalization, immune-cell-type enrichment, and phenome-wide association methods to investigate the effects of genetically predicted gene expression on ten immune-associated diseases and four cancer outcomes.

[Pulmonary Pharmacology & Therapeutics] Researchers investigated the effects of PCI-34051-induced human bronchial epithelial cells-derived exosomes on human bronchial smooth muscle cells and the key exosomal miRNAs involved in this process.

[Lung] Researchers investigated β2-adrenoceptor-mediated signaling pathways involved in the production of two pro-inflammatory cytokines, interleukin (IL)-6 and IL-8, in 16HBE14o- human bronchial epithelia.

[American Journal of Respiratory and Critical Care Medicine] Using human airway smooth muscle cells in culture as a model, the authors reported that activation of the cell surface β2-adrenoceptor, a Gs-coupled G protein-coupled receptor, evoked cAMP egress to the extracellular space.

[Pediatric Pulmonology] Human bronchial epithelial cells BEAS-2B were stimulated with transforming growth factor-β1 at a concentration of 10 ng/mL, and CCCTC-binding factor (CTCF) overexpression plasmid and CTCF small interfering RNA were transfected into the cells.

[Nature Cell Biology] Scientists showed that eosinophil extracellular traps in bronchoalveolar lavage fluid are associated with the severity of asthma in patients.