astrocytes

[Communications Biology] Scientists established a human isogenic cell line panel based on Down syndrome-specific iPSCs, the XIST-mediated transcriptional silencing system in trisomic chromosome 21, and genome/chromosome-editing technologies to eliminate phenotypic fluctuations caused by genetic variation.

[Scientific Reports] Cross-sections from injured and non-injured human spinal cords were immunolabeled for α-synuclein. This showed robust α-synuclein accumulation in profiles resembling axons and astrocytes in tissue surrounding the injury, revealing that α-synuclein markedly aggregated in traumatically injured human spinal cords.

[International Journal of Molecular Sciences] The authors summarize the various roles of astrocytes in recruiting immune cells to lesion sites, engendering the inflammatory loop, and inflicting tissue damage.

[Scientific Reports] Researchers silenced Ndufs4 in Neuro-2a cells and we observed shorter neurite lengths with decreased expression of synaptophysin.

[Archives of Pharmacal Research] We herein review a potential role of the major cellular components of the blood-brain barrier (BBB), with a focus on the contribution of BBB disruption, in neurodegenerative disease progression.

[Cell Death & Disease] Scientists generated 2D and 3D in vitro human FXS model systems based on isogenic fragile X mental retardation protein knock-out mutant and wild-type human induced pluripotent stem cell (hiPSC) lines.