Alpha-Synuclein Increases in Rodent and Human Spinal Cord Injury and Promotes Inflammation and Tissue Loss

Cross-sections from injured and non-injured human spinal cords were immunolabeled for α-synuclein. This showed robust α-synuclein accumulation in profiles resembling axons and astrocytes in tissue surrounding the injury, revealing that α-synuclein markedly aggregated in traumatically injured human spinal cords.