Tag results:
basophils
Hematopoiesis News
Signal-Transducing Adaptor Protein-1 and -2 in Hematopoiesis and Diseases
[Experimental Hematology] Recent findings have shown the critical roles of signal-transducing adaptor protein (STAP)-2 in B cell progenitor cells in marrow under hematopoietic stress and STAP-1 and -2 in BCR-ABL-transduced leukemogenesis. In this review, the authors focus on the role of STAPs in the bone marrow.
Immune Regulation News
Alveolar Macrophages Rely on GM-CSF from Alveolar Epithelial Type 2 Cells before and after Birth
[Journal of Experimental Medicine] Investigators developed new transgenic mice to profile pulmonary GM-CSF expression, which they detected in both immune cells, including group 2 innate lymphoid cells and γδ T cells, as well as AT2s.
Human Immunology News
Induction of the Apoptosis, Degranulation and IL-13 Production of Human Basophils by Butyrate and Propionate via Suppression of Histone Deacetylation
[British Journal of Immunology] Investigators elucidated the function of short chain fatty acids on human basophils. Human basophils were purified from healthy donors by flow cytometric sorting.
Dermal Cell News
Costello Syndrome Model Mice with a Hras G12S Mutation Are Susceptible to Develop House Dust Mite-Induced Atopic Dermatitis
[Cell Death & Disease] Cultured HrasG12S/+ keratinocytes exhibited increased IL-33 expression after Dermatophagoides farinae stimulation.
Hematopoiesis News
A Dynamic COVID-19 Immune Signature Includes Associations with Poor Prognosis
[Nature Medicine] Investigators identified a core peripheral blood immune signature across 63 hospital-treated patients with COVID-19 who were otherwise highly heterogeneous.