Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsInvestigators elucidated the function of short chain fatty acids on human basophils. Human basophils were purified from healthy donors by flow cytometric sorting.
[British Journal of Immunology]
6445212 UI9ND885 items 1 apa 0 default asc 1 162366 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-6412dc89db6545a999fafef3ab43a48f%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22UI9ND885%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Shi%20et%20al.%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EShi%2C%20Y.%2C%20Xu%2C%20M.%2C%20Pan%2C%20S.%2C%20Gao%2C%20S.%2C%20Ren%2C%20J.%2C%20Bai%2C%20R.%2C%20Li%2C%20H.%2C%20He%2C%20C.%2C%20Zhao%2C%20S.%2C%20Shi%2C%20Z.%2C%20Yu%2C%20F.%2C%20Xiang%2C%20Z.%2C%20%26amp%3B%20Wang%2C%20H.%20%28n.d.%29.%20Induction%20of%20the%20apoptosis%2C%20degranulation%20and%20IL-13%20production%20of%20human%20basophils%20by%20butyrate%20and%20propionate%20via%20suppression%20of%20histone%20deacetylation.%20%3Ci%3EImmunology%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fimm.13370%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fimm.13370%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DUI9ND885%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Induction%20of%20the%20apoptosis%2C%20degranulation%20and%20IL-13%20production%20of%20human%20basophils%20by%20butyrate%20and%20propionate%20via%20suppression%20of%20histone%20deacetylation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yanbiao%22%2C%22lastName%22%3A%22Shi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meizhen%22%2C%22lastName%22%3A%22Xu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shuai%22%2C%22lastName%22%3A%22Pan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sijia%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jinfeng%22%2C%22lastName%22%3A%22Ren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ruixue%22%2C%22lastName%22%3A%22Bai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hui%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cheng%22%2C%22lastName%22%3A%22He%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shuli%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhixu%22%2C%22lastName%22%3A%22Shi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fang%22%2C%22lastName%22%3A%22Yu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zou%22%2C%22lastName%22%3A%22Xiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hui%22%2C%22lastName%22%3A%22Wang%22%7D%5D%2C%22abstractNote%22%3A%22Allergic%20diseases%20are%20caused%20by%20dysregulated%20Th2%20immune%20responses%20involving%20multiple%20effector%20cells%20including%20basophils.%20Short%20chain%20fatty%20acids%20%28SCFAs%29%2C%20mainly%20acetate%2C%20propionate%20and%20butyrate%2C%20exert%20immunomodulatory%20functions%20via%20activation%20of%20its%20receptors%20GPR41%20and%20GPR43%2C%20and%20inhibition%20of%20the%20histone%20deacetylases%20%28HDACs%29%20activity.%20In%20allergic%20diseases%2C%20SCFAs%20suppress%20the%20activity%20of%20mast%20cells%2C%20eosinophils%20and%20type%202%20innate%20lymphoid%20cells%20%28ILC2%29%20but%20enhance%20the%20function%20of%20Th2%20cells.%20Here%2C%20we%20aimed%20to%20elucidate%20the%20function%20of%20SCFAs%20on%20human%20basophils.%20Human%20basophils%20were%20purified%20from%20healthy%20donors%20by%20flow%20cytometric%20sorting.%20The%20surface%20proteins%2C%20apoptosis%20and%20degranulation%20of%20basophils%20were%20analyzed%20by%20flow%20cytometric%20analysis.%20The%20mRNA%20expression%20was%20assayed%20using%20real-time%20PCR.%20Interleukin%204%20%28IL-4%29%20and%20IL-13%20were%20measured%20by%20ELISA.%20Histone%20acetylation%20was%20examined%20by%20western%20blot.%20GPR41%20was%20expressed%20by%20basophils%20and%20was%20enhanced%20by%20IL-3.%20Acetate%20induced%20intracellular%20calcium%20influx%20in%20basophils%20which%20was%20suppressed%20by%20blocking%20GPR41.%20Propionate%20and%20butyrate%2C%20but%20not%20acetate%2C%20induced%20the%20expression%20of%20CD69%20and%20IL-13.%20In%20addition%2C%20propionate%20and%20butyrate%20enhanced%20IgE-mediated%20basophil%20degranulation%20but%20inhibited%20basophil%20survival%20and%20IL-4%20secretion.%20Propionate%20and%20butyrate%20induced%20histone%20acetylation%20of%20basophils%20and%20suppression%20of%20HDACs%20activity%20mimicked%20the%20effects%20of%20propionate%20and%20butyrate%20on%20human%20basophils.%20Our%20findings%20demonstrate%20that%20propionate%20and%20butyrate%20may%20play%20a%20complex%20role%20in%20regulating%20basophil%20apoptosis%2C%20activation%20and%20degranulation%20via%20inhibiting%20HDACs%20activity.%20The%20in%20vivo%20effects%20of%20SCFAs%20on%20the%20regulation%20of%20basophil-associated%20allergic%20diseases%20need%20to%20be%20further%20explored.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fimm.13370%22%2C%22ISSN%22%3A%221365-2567%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1111%5C%2Fimm.13370%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-05-18T16%3A55%3A34Z%22%7D%7D%5D%7D
Shi, Y., Xu, M., Pan, S., Gao, S., Ren, J., Bai, R., Li, H., He, C., Zhao, S., Shi, Z., Yu, F., Xiang, Z., & Wang, H. (n.d.). Induction of the apoptosis, degranulation and IL-13 production of human basophils by butyrate and propionate via suppression of histone deacetylation. Immunology, n/a(n/a). https://doi.org/https://doi.org/10.1111/imm.13370 Cite
