Propranolol Inhibits the Angiogenic Capacity of Hemangioma Endothelia via Blocking β-Adrenoceptor in Mast Cell

Hemangioma endothelial cells were co-cultured with propranolol-treated HMC-1s supernatants, and their proliferation and apoptosis were investigated.
[Pediatric Research]
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Understanding Human Mast Cells: Lesson from Therapies for Allergic and Non-Allergic Diseases

Scientists discuss the existing and emerging therapies that target mast cells, and they consider how these treatments can help us to understand mast cell functions in disease.
[Nature Reviews Immunology]
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Lycopus lucidus Turcz Ameliorates DNCB-Induced Atopic Dermatitis in BALB/C Mice

The authors determined whether Lycopus lucidus Turcz (LLT) could improve 2,4‑dinitrochlorobenzene‑induced dermatitis and to verify the inhibitory effect of LLT on the expression of chemokines and pro‑inflammatory cytokines in the HaCaT immortalized keratinocyte cell line.
[Molecular Medicine Reports]
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Disrupted Homeostasis of Synovial Hyaluronic Acid and Its Associations with Synovial Mast Cell Proteases of Rheumatoid Arthritis Patients and Collagen-Induced Arthritis Rats

The authors explored the correlations between hyaluronic acid (HA) concentration versus mast cell proteases, or matrix metalloproteinase-2/9 and investigated the association of mast cell-specific proteases with disrupted synovial HA homeostasis in rheumatoid arthritis or collagen-induced arthritis rats.
[Immunologic Research]
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Pimecrolimus Interferes the Therapeutic Efficacy of Human Mesenchymal Stem Cells in Atopic Dermatitis by Regulating NFAT-COX2 Signaling

Researchers investigated whether coadministration with pimecrolimus, one of the topical calcineurin inhibitors, could influence the therapeutic potential of human umbilical cord blood MSCs in atopic dermatitis.
[Stem Cell Research & Therapy]
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Mast Cell Function in Prostate Inflammation, Fibrosis, and Smooth Muscle Cell Dysfunction

As opposed to symptomatic uropathogenic E. coli-infected mice, treated mice showed reduced myosin light chain-2 phosphorylation, a marker of prostate smooth muscle contraction.
[American Journal of Physiology-Renal Physiology]
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AB Science Announces That It Has Received the First Authorization to Resume Patient Enrollment in the Confirmatory Phase III Study of Masitinib (AB19001) in ALS

AB Science SA announced that it has received the first authorization to resume patient enrollment in the confirmatory Phase III study of masitinib in amyotrophic lateral sclerosis (ALS). Masitinib is a orally administered tyrosine kinase inhibitor that targets mast cells and macrophages, important cells for immunity, through inhibiting a limited number of kinases.
[AB Science SA]
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Eosinophilic Gastritis/Gastroenteritis

The authors present the current literature regarding the clinical presentation, diagnostic criteria, and management of eosinophilic gastritis/gastroenteritis.
[Current Gastroenterology Reports]
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A Novel Approach for Studying Mast Cell-Driven Disorders: Mast Cells Derived from Induced Pluripotent Stem Cells

Investigators developed a novel strategy for the rapid and efficient differentiation of mast cells from human iPSCs.
[Journal of Allergy and Clinical Immunology]
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Immune Cell Analyses of the Tumor Microenvironment in Prostate Cancer Highlight Infiltrating Regulatory T Cells and Macrophages as Adverse Prognostic Factors

The authors characterized and assessed the prognostic potential of distinct immune cell infiltration patterns in the prostate tumor microenvironment.
[Journal of Pathology]
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Induction of the Apoptosis, Degranulation and IL-13 Production of Human Basophils by Butyrate and Propionate via Suppression of Histone Deacetylation

Investigators elucidated the function of short chain fatty acids on human basophils. Human basophils were purified from healthy donors by flow cytometric sorting.
[British Journal of Immunology]
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