The authors demonstratef that the splenic microenvironment, specifically 15-PGDH high-expressing macrophages, megakaryocytes, and mast cells, regulated steady-state hematopoiesis and potentiated recovery after bone-marrow transplantation.
[JCI Insight]
Smith, J. N. P., Dawson, D. M., Christo, K. F., Jogasuria, A. P., Cameron, M. J., Antczak, M. I., Ready, J. M., Gerson, S. L., Markowitz, S. D., & Desai, A. B. (2021). 15-PGDH inhibition activates the splenic niche to promote hematopoietic regeneration. JCI Insight. https://doi.org/10.1172/jci.insight.143658 Cite
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