Scientists created the first 3D adipose tissue organoid model which could contain and maintain resident immune cell populations of the stromal vascular fraction and proved to be effective in studying adipose tissue biology in a convenient manner.
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Taylor, J., Sellin, J., Kuerschner, L., Krähl, L., Majlesain, Y., Förster, I., Thiele, C., Weighardt, H., & Weber, E. (2020). Generation of immune cell containing adipose organoids for in vitro analysis of immune metabolism. Scientific Reports, 10(1), 21104. https://doi.org/10.1038/s41598-020-78015-9 Cite
The authors evaluate evidence for a layered hematopoietic system across species. They discuss mechanisms and selective pressures leading to the temporal generation of different cell types.
[Frontiers in Cell and Developmental Biology]
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Researchers hypothesized that head and neck squamous cell carcinoma recurrent tumors successfully evade anti-tumor immune response and aimed to reveal tumor immune microenvironment changes of primary tumors.
[Clinical Cancer Research]
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Watermann, C., Pasternack, H., Idel, C., Ribbat-Idel, J., Brägelmann, J., Kuppler, P., Offermann, A., Jonigk, D., Kühnel, M., Schröck, A., Dreyer, E., Rosero, C., Nathansen, J., Dubrovska, A., Tharun, L., Kirfel, J., Wollenberg, B., Perner, S., & Krupar, R. (2020). Recurrent HNSCC harbor an immunosuppressive tumor immune microenvironment suggesting successful tumor immune evasion. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-0197 Cite
Investigators combined immune landscape signatures with hepatocellular carcinoma clinical and prognostic features to classify them into distinct subtypes. The immunogenomic profiles, stromal cell features and immune cell composition of the subtypes were then systematically analyzed.
Scientists elucidated the function and possible role of a novel lncRNA, called lncRNA-AK149641, in the mechanism of lipopolysaccharide-induced inflammatory response in P815 mast cells.
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Zhou, Y., Gu, L., Zhang, J., Pan, J., Zhang, J., Zhao, D., & Liu, F. (2020). LncRNA-AK149641 regulates the secretion of tumor necrosis factor-α in P815 mast cells by targeting the nuclear factor-kappa B signaling pathway. Scientific Reports, 10(1), 16655. https://doi.org/10.1038/s41598-020-73186-x Cite
Using cytokine array screening, scientists found that autophagy deficiency inhibited the transcription and production of the cytokine CCL2/MCP-1 by TNF.
Telocytes acquired immunological features of endocrine cells that exhibited high affinity for silver stain, performic acid with methylene blue, Marsland stain, and immunohistochemical staining using chromogranin A.
Investigators evaluated the effects of an anti-Siglec-8 monoclonal antibody in non-allergic disease models of experimental cigarette-smoke-induced chronic obstructive pulmonary disease and bleomycin-induced lung injury in Siglec-8 transgenic mice.
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Schanin, J., Gebremeskel, S., Korver, W., Falahati, R., Butuci, M., Haw, T. J., Nair, P. M., Liu, G., Hansbro, N. G., Hansbro, P. M., Evensen, E., Brock, E. C., Xu, A., Wong, A., Leung, J., Bebbington, C., Tomasevic, N., & Youngblood, B. A. (2020). A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation. Mucosal Immunology, 1–11. https://doi.org/10.1038/s41385-020-00336-9 Cite
Cultured HrasG12S/+ keratinocytes exhibited increased IL-33 expression after Dermatophagoides farinae stimulation.
[Cell Death & Disease]
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Katata, Y., Inoue, S., Asao, A., Kobayashi, S., Terui, H., Inoue-Shibui, A., Abe, T., Niihori, T., Aiba, S., Ishii, N., Kure, S., & Aoki, Y. (2020). Costello syndrome model mice with a Hras G12S mutation are susceptible to develop house dust mite-induced atopic dermatitis. Cell Death & Disease, 11(8), 1–15. https://doi.org/10.1038/s41419-020-02845-8 Cite
Wild‐type, KitW‐sh, and Mdr2‐/‐ mice lacking l‐histidine decarboxylase were injected with vehicle or PKH26‐tagged murine mast cells pretreated with 0.01% DMSO or the TGF‐βR inhibitor,
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Scientists investigated the epigenetic regulation of promoters and gene bodies and their effect on the tumor microenvironment composition of cutaneous malignant peripheral nerve sheath tumors and spindle cell melanomas.
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